Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice

@inproceedings{Shytle2012OptimizedTE,
  title={Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer’s Transgenic Mice},
  author={R Douglas Shytle and Jun Tan and Paula C Bickford and Kavon Rezai-zadeh and Lei Hou and Jin Zeng and Paul R. Sanberg and Cyndy Davis Sanberg and Randall S. Alberte and Ryan C Fink and Bill Roschek},
  booktitle={Current Alzheimer research},
  year={2012}
}
In a previous in vitro study, the standardized turmeric extract, HSS-888, showed strong inhibition of Aβ aggregation and secretion in vitro, indicating that HSS-888 might be therapeutically important. Therefore, in the present study, HSS-888 was evaluated in vivo using transgenic 'Alzheimer' mice (Tg2576) over-expressing Aβ protein. Following a six-month… CONTINUE READING
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