Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells

  title={Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells},
  author={Lamya H. Naser Al-Wahaibi and Muneera S. M. Al-Saleem and Osama Abdelhakim Aly Ahmed and Usama Ahmed Fahmy and Nabil Abdulhafiz Alhakamy and Basma Ghazi Eid and Ashraf B. Abdel-Naim and Wael M Abdel-Mageed and Maha M Alrasheed and Gamal A Shazly},
  journal={International Journal of Molecular Sciences},
Accumulating evidence indicates that statins reduce the risk of different cancers and inhibit the proliferation of liver cancer cells. This study aims to explore whether the electrostatic conjugation of optimized fluvastatin (FLV) to human immunodeficiency virus type 1 (HIV-1) trans-activator transcription peptide (TAT) would enhance the anti-proliferative activity against HepG2 cells. FLV–TAT conjugation was optimized to achieve the lowest size with highest zeta potential. Nine formulae were… 

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