Optimization of thein vitro glucuronidation of ibuprofen using factorial design

Abstract

Ibuprofen was chosen as a test compound to perform a multivariate design in order to determine the highest yield of thein vitro glucuronidation reaction in relation to the concentration of reacting and activating substances. Preliminary studies with a univariate design indicated that the concentration of Mg2+ had no significant effect on the glucuronidation… (More)
DOI: 10.1007/BF01959417

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Cite this paper

@article{Niemeijer1989OptimizationOT, title={Optimization of thein vitro glucuronidation of ibuprofen using factorial design}, author={Nico R. Niemeijer and Jan H. de Boer and Thijs K. Gerding and Prof. Dr. Rokus A. de Zeeuw}, journal={Pharmaceutisch Weekblad}, year={1989}, volume={11}, pages={232-235} }