Optimization of the retention properties of vincristine in liposomal systems.

@article{Boman1993OptimizationOT,
  title={Optimization of the retention properties of vincristine in liposomal systems.},
  author={Nancy L. Boman and Lawrence D. Mayer and Pieter R Cullis},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1152 2},
  pages={253-8}
}
The influence of lipid composition, internal pH and internal buffering capacity on the retention properties of vincristine loaded into large unilamellar vesicle (LUV) systems in response to transmembrane pH gradients has been assessed. It is shown that increasing the (saturated) acyl chain length of the phosphatidylcholine molecule, increasing the internal buffering capacity, and decreasing the internal pH all result in increased drug retention. Further, a study of the pH dependence on the… CONTINUE READING