Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.

@article{Bell1995OptimizationOT,
  title={Optimization of the potency and duration of action of N-hydroxyurea 5-lipoxygenase inhibitors.},
  author={Randy L. Bell and Jennifer B. Bouska and Peter E. Malo and Cristina Lanni and Richard R Harris and E R Otis and Andrew O. Stewart and Dee W. Brooks and George W. Carter},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={724-31}
}
As in vitro glucuronidation assay and several biochemical assays were utilized to discover potent new N-hydroxyurea-containing 5-lipoxygenase inhibitors with long durations of action. The best of these, A-78773, is a racemic mixture of two enantiomers. These enantiomers were purified and the R(+)-enantiomer A-79175 was found to be superior to the S… CONTINUE READING