Optimization of the mobile phase composition for preparative chiral separation of flurbiprofen enantiomers

@article{Ribeiro2009OptimizationOT,
  title={Optimization of the mobile phase composition for preparative chiral separation of flurbiprofen enantiomers},
  author={Ant{\'o}nio E Ribeiro and N. Graca and L. Pais and A. Rodrigues},
  journal={Separation and Purification Technology},
  year={2009},
  volume={68},
  pages={9-23}
}
  • António E Ribeiro, N. Graca, +1 author A. Rodrigues
  • Published 2009
  • Chemistry
  • Separation and Purification Technology
  • Abstract This work presents the experimental and simulation results obtained for the optimization of the mobile phase composition for the preparative separation of flurbiprofen enantiomers by liquid chromatography using an amylose-based chiral stationary phase (Chiralpak AD). The experimental work carried out includes solubility and adsorption isotherm measurements and pulse and breakthrough experiments under preparative conditions. The simulation work predicts the operation of a simulated… CONTINUE READING
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