Optimization of the microenvironment for mammalian cell culture in flexible collagen microspheres in a fluidized-bed bioreactor.

@article{Vournakis1991OptimizationOT,
  title={Optimization of the microenvironment for mammalian cell culture in flexible collagen microspheres in a fluidized-bed bioreactor.},
  author={John N. Vournakis and Peter W. Runstadler},
  journal={Biotechnology},
  year={1991},
  volume={17},
  pages={305-26}
}
Flexible, three-dimensional, collagen Microspheres have been developed to actively promote a natural, optimal microenvironment for large-scale tissue culture of mammalian cells. The transport of nutrients into and cell products out of the Microspheres is enhanced by forced convective flow, which is the result of the tumbling of Microspheres and the dynamic… CONTINUE READING