Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit

  title={Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit},
  author={Melissa R Gaddy and Sercan Yildiz and Jan Unkelbach and D{\'a}vid Papp},
  journal={Physics in Medicine \& Biology},
Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, can potentially lower treatment side effects without compromising tumor control. This can be achieved by hypofractionating parts of the tumor while delivering approximately uniformly fractionated doses to the surrounding tissue. Plan optimization for such treatments is based on biologically effective dose (BED); however, this leads to computationally challenging nonconvex… 

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