Optimization of small-molecule inhibitors of influenza virus polymerase: from thiophene-3-carboxamide to polyamido scaffolds.

@article{Lepri2014OptimizationOS,
  title={Optimization of small-molecule inhibitors of influenza virus polymerase: from thiophene-3-carboxamide to polyamido scaffolds.},
  author={Susan Lepri and Giulio Nannetti and Giulia Muratore and Gabriele Cruciani and Renzo Ruzziconi and Beatrice Mercorelli and Giorgio Pal{\`u} and Arianna Loregian and Laura Goracci},
  journal={Journal of medicinal chemistry},
  year={2014},
  volume={57 10},
  pages={
          4337-50
        }
}

• Susan Lepri, Giulio Nannetti, +6 authors Laura Goracci
• Published in Journal of medicinal chemistry 2014
• DOI:10.1021/jm500300r

Influenza virus infections represent a serious concern to public health, being characterized by high morbidity and significant mortality. To date, compounds targeting the viral ion-channel M2 or the viral neuraminidase are the drugs available for treatment of influenza, but the emergence of drug-resistant viral mutants renders the search for novel targets and their possible inhibitors a major priority. Recently, we demonstrated that the viral RNA-dependent RNA polymerase (RdRP) complex can be… CONTINUE READING

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