Optimization of siRNA delivery to target sites: issues and future directions.

@article{Khalil2018OptimizationOS,
  title={Optimization of siRNA delivery to target sites: issues and future directions.},
  author={Ikramy A. Khalil and Yuma Yamada and Hideyoshi Harashima},
  journal={Expert opinion on drug delivery},
  year={2018},
  volume={15 11},
  pages={
          1053-1065
        }
}
INTRODUCTION The discovery of RNA interference (RNAi) earned the 2006 Nobel Prize in Physiology or Medicine for its biological significance and potential for developing novel therapeutics. The small interfering RNA (siRNA) is the most promising tool for translating RNAi to clinical use. Efforts are ongoing to improve siRNA delivery through developing novel biomaterials and delivery strategies. Given time, it appears that siRNA drugs will eventually become a reality. Areas covered: The currently… CONTINUE READING
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