Optimization of retroviral vector-mediated gene transfer into endothelial cells in vitro.

Abstract

Retroviral vector-mediated gene transfer into endothelial cells is relatively inefficient with transduction rates as low as 1-2% in vitro and even lower in vivo. To increase the efficiency of gene transfer into endothelial cells, we used retroviral vectors expressing beta-galactosidase and urokinase and measured endothelial cell transduction efficiencies… (More)

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@article{Kahn1992OptimizationOR, title={Optimization of retroviral vector-mediated gene transfer into endothelial cells in vitro.}, author={Mark L. Kahn and S. W. Lee and David A. Dichek}, journal={Circulation research}, year={1992}, volume={71 6}, pages={1508-17} }