Optimization of primaquine diphosphate tablet formulation for controlled drug release using the mixture experimental design.


A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constraints on the proportions of the components was employed to obtain tablet compositions. Drug release… (More)
DOI: 10.3109/10837450.2012.693508