Optimization of pediatric rheumatology therapeutics.

  title={Optimization of pediatric rheumatology therapeutics.},
  author={Mara Becker},
  journal={Clinical pharmacology and therapeutics},
  volume={91 4},
Therapeutics used in pediatric rheumatology have evolved substantially over the past few decades; they currently target specific cytokines that are known to be involved in the pathophysiology of these complex diseases. The field is limited by a lack of full understanding of the etiology and pathophysiology of these conditions, as well as by the rarity of these diseases in the pediatric population. Advances in biomarkers, pharmacogenomics, and biologic therapies, along with a more unified effort… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 87 references

Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus

Sagcal-Gironella, A.C
Semin. Arthritis Rheum • 2011

The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response

Becker, M.L
Arthritis Rheum • 2011

initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features

Beukelman, T. et al. 2011 American College of Rheumatology recom arthritis
Arthritis Care Res. (Hoboken). 63, 465–482 • 2011

new insights into classification, measures of outcome, and pharmacotherapy

Beresford, M. W. Juvenile idiopathic arthritis
Paediatr. Drugs 13, 161–173 • 2011

results from a phase III study

Ruperto, N. Efficacy, safety of canakinumab, a long acting fully human anti-Interleukin-1b antibody, in systemic juvenile idiopathic arthritis with active features
Pediatric Rheumatology 9 (suppl. 1), O21 • 2011

Analysis of intracellular methotrexate polyglutamates in juvenile idiopathic arthritis : Effect of route of administration upon intracellular methotrexate polyglutamate variability

M. L. Becker
Arthritis Rheum . • 2010

Similar Papers

Loading similar papers…