Optimization of nonviral gene transfer of vascular smooth muscle cells in vitro and in vivo.

@article{Armeanu2000OptimizationON,
  title={Optimization of nonviral gene transfer of vascular smooth muscle cells in vitro and in vivo.},
  author={Sorin Armeanu and Jaroslav Pelisek and Eberhard Krausz and Anja G. Fuchs and Detlef Groth and Ren{\'e} Curth and Oliver Keil and Jill L. Quilici and Pierre Henri Rolland and Regina Dr Reszka and Sigrid Nikol},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2000},
  volume={1 4},
  pages={
          366-75
        }
}
Gene therapy strategies for the prevention of restenosis postangioplasty are promising. Nonviral gene transfer to the arterial wall in vivo has so far been limited by poor efficiency. This study aimed to optimize transfection of primary vascular smooth muscle cells using cationic nonviral formulations based on cholesterol derivates (DC-, DAC-, DCQ-, and Sp-Chol), double-chained amphiphils (LipofectAMINE, DOTMA, DOSGA, DOSPER, and DOCSPER), or heterogeneous reagents (Superfect, Effectene, and… CONTINUE READING
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