Optimization of ligand presentation for immunoadsorption using star-configured polyethylene glycols.

Abstract

Medical, pharmaceutical, and industrial applications of immunoadsorption are frequently limited by the technologic problems of low affinity, inadequate capacity, hydrophobicity, and bioincompatibility. To overcome these difficulties we studied the use of star-burst configured polyethylene glycols (star-PEGs) with immunoreactive molecules covalently bound to… (More)

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