Optimization of irinotecan chronotherapy with P-glycoprotein inhibition.

  title={Optimization of irinotecan chronotherapy with P-glycoprotein inhibition.},
  author={Elisabeth Filipski and Elodie Berland and Narin Ozturk and Catherine Guettier and Gijsbertus T. J. van der Horst and Francis A L{\'e}vi and Alper Okyar},
  journal={Toxicology and applied pharmacology},
  volume={274 3},
The relevance of P-glycoprotein (P-gp) for irinotecan chronopharmacology was investigated in female B6D2F1 mice. A three-fold 24h change in the mRNA expression of Abcb1b was demonstrated in ileum mucosa, with a maximum at Zeitgeber Time (ZT) 15 (p<0.001). No rhythm was found for abcb1a in ileum mucosa, or for Abcb1a/b in Glasgow osteosarcoma (GOS), a mouse… CONTINUE READING