Optimization of fed-batch fermentors by iterative dynamic programming.

  • Rein Luus
  • Published 1993 in Biotechnology and bioengineering


By using penalty functions to handle state constraints, iterative dynamic programming can be used in a straightforward manner for the optimization of fed-batch fermentors. No computational difficulties were encountered and better results are obtained than previously reported in the literature for a fed-batch fermentor for biosynthesis of penicillin. 


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