Optimization of drug-eluting balloon use for safety and efficacy: evaluation of the 2nd generation paclitaxel-eluting DIOR-balloon in porcine coronary arteries.

@article{Psa2010OptimizationOD,
  title={Optimization of drug-eluting balloon use for safety and efficacy: evaluation of the 2nd generation paclitaxel-eluting DIOR-balloon in porcine coronary arteries.},
  author={Anik{\'o} P{\'o}sa and No{\'e}mi Nyolczas and Rayyan Hemetsberger and Noemi Pavo and Ors Petneh{\'a}zy and Zsolt Petr{\'a}si and Giuseppe Massimo Sangiorgi and Mariann Gy{\"o}ngy{\"o}si},
  journal={Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions},
  year={2010},
  volume={76 3},
  pages={395-403}
}
OBJECTIVES The aim of this preclinical study was to optimize the use of drug-eluting balloon (DEB) DIOR(2nd) (generation) by measurements of tissue and plasma paclitaxel concentrations in porcine coronary artery overstretch and prove efficacy in inhibition of neointimal growth without complementary use of stent. BACKGROUND The usually recommended DEB 60 sec inflation time causes prolonged ischemia and arterial injury. METHODS Tissue, plasma, and balloon surface concentrations of paclitaxel… CONTINUE READING