Optimization of conditions for the liquid chromatographic-electrospray lonization-mass spectrometric analysis of amnesic shellfish poisoning toxins

@article{Pieiro2001OptimizationOC,
  title={Optimization of conditions for the liquid chromatographic-electrospray lonization-mass spectrometric analysis of amnesic shellfish poisoning toxins},
  author={N. Pi{\~n}eiro and E. Vaquero and J. M. Le{\~a}o and A. Gogo-Mart{\'i}nez and J. Rodr{\'i}guez V{\'a}zquez},
  journal={Chromatographia},
  year={2001},
  volume={53},
  pages={S231-S235}
}
SummaryIn this paper we report results obtained from analysis of domoic acid and its analogues, toxins responsible for incidents of amnesic shellfish poisoning (ASP) in several places world-wide, by use of liquid chromatography coupled with electrospray ionization mass spectrometry. Different chromatographic and mass spectrometry conditions were evaluated with the aim of achieving the best chromatographic performance combined with the optimum mass spectrometric response. From the results… Expand
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References

SHOWING 1-5 OF 5 REFERENCES
Comparison of UV absorption and electrospray mass spectrometry for the high-performance liquid chromatographic determination of domoic acid in shellfish and biological samples.
TLDR
This study demonstrates the use of HPLC-ESI-MS-SIM for the routine confirmation of domoic acid in a wide variety of samples and indicated that extracts found positive by theHPLC-UV method could be readily confirmed directly by HPLC/ESI/MS/SIM without additional sample treatment. Expand
Ion-spray mass spectrometry of marine neurotoxins.
TLDR
Combining liquid chromatography with ion-spray mass spectrometry allowed the determination of domoic acid and some of its isomers in toxic shellfish tissue extracts and provided useful fragment-ion spectra for all compounds. Expand
Rapid Extraction and Cleanup for Liquid Chromatographic Determination of Domoic Acid in Unsalted Seafood
Domoic acid is the toxin responsible for incidents of amnesic shellfish poisoning. A rapid extraction and cleanup for the liquid chromatographic determination of domoic acid in unsalted seafood isExpand
Analysis of domoic acid isomers in seafood by capillary electrophoresis
TLDR
Comparison with LC showed that comparable precision and accuracy could be attained by the two techniques for the analysis of domoic acid based upon capillary electrophoresis combined with UV absorbance detection. Expand
Pennate Diatom Nitzschia pungens as the Primary Source of Domoic Acid, a Toxin in Shellfish from Eastern Prince Edward Island, Canada
TLDR
An outbreak of food poisoning in Canada during autumn 1987 was traced to cultured blue mussels (Mytilus edulis) from the Cardigan Bay region of eastern Prince Edward Island and represents the first known occurrence of human poisoning by this neurotoxin. Expand