• Computer Science, Medicine, Biology
  • Published in Briefings in Bioinformatics 2016
  • DOI:10.1093/bib/bbw082

Optimization of cell lines as tumour models by integrating multi-omics data

@article{Zhao2016OptimizationOC,
  title={Optimization of cell lines as tumour models by integrating multi-omics data},
  author={Ning Zhao and Yongjing Liu and Yunzhen Wei and Zichuang Yan and Qiang Zhang and Cheng Wu and Zhi-qiang Chang and Yan Xu},
  journal={Briefings in bioinformatics},
  year={2016},
  volume={18 3},
  pages={
          515-529
        }
}
Cell lines are widely used as in vitro models of tumorigenesis. However, an increasing number of researchers have found that cell lines differ from their sourced tumour samples after long-term cell culture. The application of unsuitable cell lines in experiments will affect the experimental accuracy and the treatment of patients. Therefore, it is imperative to identify optimal cell lines for each cancer type. Here, we review the methods used to evaluate cell lines since 2005. Furthermore, gene… CONTINUE READING
1
Twitter Mention

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2015