Optimization of carboxymethyl chitosan synthesis using response surface methodology and desirability function.


In this paper, chitosan was reacted with monochloroacetic acid under alkaline conditions to prepare carboxymethyl chitosan. A 2(3) full-factorial central composite design was applied to evaluate the effect of molar ratio sodium hydroxide (NaOH)/Chitosan (Ch), time and molar ratio monochloroacetic acid (MCA)/Chitosan (Ch) on the reaction yield and on the… (More)
DOI: 10.1016/j.ijbiomac.2016.01.017


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