Optimization of an amplification protocol for misfolded proteins by using relaxed control.


We investigate an optimal control problem which arises in the optimization of an amplification technique for misfolded proteins. The improvement of this technique may play a role in the detection of prion diseases. The model consists in a linear system of differential equations with a nonlinear control. The appearance of oscillations in the numerical… (More)
DOI: 10.1007/s00285-014-0768-9


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