Optimization of amorphadiene synthesis in bacillus subtilis via transcriptional, translational, and media modulation.

@article{Zhou2013OptimizationOA,
  title={Optimization of amorphadiene synthesis in bacillus subtilis via transcriptional, translational, and media modulation.},
  author={Kang Zhou and Ruiyang Zou and Congqiang Zhang and Gregory Stephanopoulos and Heng-Phon Too},
  journal={Biotechnology and bioengineering},
  year={2013},
  volume={110 9},
  pages={
          2556-61
        }
}
  • Kang Zhou, Ruiyang Zou, +2 authors Heng-Phon Too
  • Published in
    Biotechnology and…
    2013
  • Chemistry, Medicine
  • Genetically engineered microbes have been intensively investigated as a means for the cost-effective production of isoprenoids. Bacillus subtilis is a promising microbial host for this purpose because of its fast growth rate and GRAS (generally regarded as safe) status. To date, development of this host has been impaired by the lack of genetic tools for modulating the expression of multiple genes. In this study, we present a novel two-promoter system which can be used to independently control… CONTINUE READING

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