Optimization of allograft implantation using scaffold-free chondrocyte plates.

@article{Nagai2008OptimizationOA,
  title={Optimization of allograft implantation using scaffold-free chondrocyte plates.},
  author={Toshihiro Nagai and Masato Sato and Katsuko S. Furukawa and Toshiharu Kutsuna and Naoshi Ohta and T. Ushida and Joji Mochida},
  journal={Tissue engineering. Part A},
  year={2008},
  volume={14 7},
  pages={1225-35}
}
If a tissue-engineered cartilage transplant is to succeed, it needs to integrate with the host tissue, to endure physiological loading, and to acquire the phenotype of the articular cartilage. Although there are many reported treatments for osteochondral defects of articular cartilage, problems remain with the use of artificial matrices (scaffolds) and the stage of implantation. We constructed scaffold-free three-dimensional tissue-engineered cartilage allografts using a rotational culture… CONTINUE READING
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