Optimization of a formulation containing viable lactic acid bacteria.

  title={Optimization of a formulation containing viable lactic acid bacteria.},
  author={Maria Stadler and Helmut Viernstein},
  journal={International journal of pharmaceutics},
  volume={256 1-2},
In the present study, gastric juice resistant tablet formulations of lactic acid bacteria (LAB) were developed, using hydroxypropylmethylcellulose acetate succinate (HPMCAS) as well as alginates, apple pectin and Metolose as matrix forming components. To optimize the formulation-using survival rate in acid medium, and disintegration time in intestinal fluid as test parameters-tablets were modified with respect to LAB content, amount of applied excipients per tablet, and compaction forces. A… CONTINUE READING


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