Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo

@article{Sternberg2016OptimizationOA,
  title={Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo},
  author={Jenna R Sternberg and Kristen Eileen Severi and Kevin Fidelin and Johanna Gomez and Hideshi Ihara and Yara Alcheikh and Jeffrey Michael Hubbard and Koichi Kawakami and Maximiliano L. Suster and Claire Wyart},
  journal={Current Biology},
  year={2016},
  volume={26},
  pages={2319-2328}
}
Precise control of speed during locomotion is essential for adaptation of behavior in different environmental contexts [1-4]. A central question in locomotion lies in understanding which neural populations set locomotor frequency during slow and fast regimes. Tackling this question in vivo requires additional non-invasive tools to silence large populations of neurons during active locomotion. Here we generated a stable transgenic line encoding a zebrafish-optimized botulinum neurotoxin light… CONTINUE READING
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