Optimization of a Mixture of an Agonist and an Antagonist of the GABA-Receptor System According to the Safety Criterion

@article{Sylantyev2004OptimizationOA,
  title={Optimization of a Mixture of an Agonist and an Antagonist of the GABA-Receptor System According to the Safety Criterion},
  author={Sergiy Sylantyev and Vladimir G Zinkovsky},
  journal={Neurophysiology},
  year={2004},
  volume={34},
  pages={243-246}
}
Based on the interaction between various types of pharmacologically active substances, equations of general form were derived that enable us to optimize an agonist-antagonist mixture on the criterion of the maximum safety of application, i.e., the therapeutic index. The character of changes of the therapeutic index of a mixture of pharmacologically active… CONTINUE READING