Optimization of Tablet Formulations Based on Starch/Lactose Granulations for Use in Tropical Countries

@article{Bos1991OptimizationOT,
  title={Optimization of Tablet Formulations Based on Starch/Lactose Granulations for Use in Tropical Countries},
  author={C. E. Bos and G. K. Bolhuis and Coenraad F. Lerk},
  journal={Drug Development and Industrial Pharmacy},
  year={1991},
  volume={17},
  pages={2373-2389}
}
AbstractSeveral granulations consisting of α-lactose monohydrate 200 mesh and native starch (corn, potato, rice or tapioca) were prepared. The influence of starch concentration, storage temperature and relative humidity on the physical properties of the tablets prepared from these granulations was estimated. Two granulations, which resulted in tablets with adequate initial values of crushing strength and disintegration time and with an acceptable physical stability were selected as standard… 
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