• Corpus ID: 16546441

Optimization of Roll Compaction / Dry Granulation ( Rcdg ) Process for Poorly Flowable Antiviral Formulation

@inproceedings{Kaur2012OptimizationOR,
  title={Optimization of Roll Compaction / Dry Granulation ( Rcdg ) Process for Poorly Flowable Antiviral Formulation},
  author={Gurpreet Kaur and Deepak Sridhar and Manoj K Gera},
  year={2012}
}
In this investigation, roll compaction/dry granulation (RCDG) process was optimized for formulation of model amorphous drug candidate with fine-fluffy nature and poor flowability. Three operating parameters the roller speed, the hydraulic pressure and the granulator speed on the Alexanderwerk WP 120 Pharma Roll Compactor were varied. The planned response variable for study was % retention over #60 BSS mesh. The number of compaction cycles required to get not less than 90% retention over #60 BSS… 
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