Optimization of Noscapine-Loaded mPEG-PLGA Nanoparticles and Release Study: a Response Surface Methodology Approach

Abstract

The aim of this study was to incorporate noscapine (Nos) into methoxy poly (ethylene glycol)-poly (lactide-co-glycolide) (mPEG-PLGA) nanoparticles and optimize its size, entrapment efficacy% (EE%), and drug loading% (DL%). Nanoprecipitation was employed for preparation of the nanoparticles. In this respect, the Box–Behnken experimental design was applied to… (More)
DOI: 10.1007/s12247-018-9318-0

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