Optimization of Multimeric Human Papillomavirus L2 Vaccines

  title={Optimization of Multimeric Human Papillomavirus L2 Vaccines},
  author={Subhashini Jagu and Kihyuck Kwak and Balasubramanyam Karanam and Warner K Huh and Vijayarangam Damotharan and Sudha V. Chivukula and Richard B. S. Roden},
  booktitle={PloS one},
We sought to define the protective epitopes within the amino terminus of human papillomavirus (HPV) type 16 minor capsid protein L2. Passive transfer of mice with rabbit antisera to HPV16 L2 peptides 17-36, 32-51 and 65-81 provided significant protection against vaginal HPV16 challenge, whereas antisera to 47-66, 108-120 or 373-392 did not. Vaccination with L1 virus-like particles induces a high titer, but generally type-restricted neutralizing antibody response. Conversely, vaccination with L2… CONTINUE READING

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