Optimization of Isolation and Further Molecular and Functional Characterization of SSEA-4 + /Oct-4 + /CD133 + /CXCR4 + /LIN neg /CD45 neg Very Small Embryonic-Like (VSEL) Stem Cells Isolated from Umbilical Cord Blood.

@inproceedings{ZubaSurma2008OptimizationOI,
  title={Optimization of Isolation and Further Molecular and Functional Characterization of SSEA-4 + /Oct-4 + /CD133 + /CXCR4 + /LIN neg /CD45 neg Very Small Embryonic-Like (VSEL) Stem Cells Isolated from Umbilical Cord Blood.},
  author={Ewa K. Zuba-Surma and Magdalena J. Kucia and Izabela Klich and Nicholas James Greco and Mary L. Laughlin and Philip H. Paul and Mariusz Z. Ratajczak and Janina Ratajczak},
  year={2008}
}
Several lines of evidence support the hypothesis that pluripotent stem cells (PSCs) reside in human tissues. Recently, we identified a population of very small embryonic-like (VSEL) SCs in umbilical cord blood (CB) (Leukemia2007;21:297-303). These VSELs are: i) very small in size ( + /Oct-4 + /CD133 + /CD34 + /CXCR4 + /Lin neg / CD45 neg ; iii) responsive to a stromal derived factor (SDF)-1 gradient; and iv) possess large nuclei that contain primitive euchromatin. In the current study, we… CONTINUE READING