Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry

@inproceedings{Hasselbach2014OptimizationOH,
  title={Optimization of High Grade Glioma Cell Culture from Surgical Specimens for Use in Clinically Relevant Animal Models and 3D Immunochemistry},
  author={Laura A. Hasselbach and Susan M. Irtenkauf and Nancy W. Lemke and Kevin K. Nelson and Artem D. Berezovsky and Enoch T. Carlton and Andrea D. Transou and T. G. Mikkelsen and Ana C deCarvalho},
  booktitle={Journal of visualized experiments : JoVE},
  year={2014}
}
Glioblastomas, the most common and aggressive form of astrocytoma, are refractory to therapy, and molecularly heterogeneous. The ability to establish cell cultures that preserve the genomic profile of the parental tumors, for use in patient specific in vitro and in vivo models, has the potential to revolutionize the preclinical development of new treatments for glioblastoma tailored to the molecular characteristics of each tumor. Starting with fresh high grade astrocytoma tumors dissociated… CONTINUE READING
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