Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments

@inproceedings{Cervera2011OptimizationOH,
  title={Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments},
  author={Laura Cervera and Sonia San Mart{\'i}n Guti{\'e}rrez and Francesc G{\`o}dia and Mar{\'i}a Mercedes Segura},
  booktitle={BMC proceedings},
  year={2011}
}
Background Mammalian cells are a widely used expression platform for the production of recombinant therapeutic proteins or viral particle-based vaccines since they typically perform appropriate protein post-translational modifications and authentic viral particle assembly. Of the available mammalian cells, HEK 293 is one of the most industrially relevant cell lines because it is cGMP compliant and is able to grow in suspension in a variety of commercial serum-free media. Of note, production of… CONTINUE READING

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