Optimization of DNA vaccination against cutaneous leishmaniasis.

  title={Optimization of DNA vaccination against cutaneous leishmaniasis.},
  author={Susana M{\'e}ndez and Yasmine Belkaid and Robert A. Seder and David Sacks},
  volume={20 31-32},
The present studies were designed to examine the requirements of dose, route of inoculation and constituent antigens for the maintenance of complete and long lasting protection against cutaneous leishmaniasis due to Leishmania major conferred by a cocktail DNA vaccine encoding the Leishmania antigens LACK, LmST11 and TSA. Vaccination of C57Bl/6 mice with LACK DNA alone resulted in partial protection, whereas the combination of LmST11 and TSA provided stronger, though still incomplete protection… CONTINUE READING