Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

@inproceedings{Nedialkova2015OptimizationOC,
  title={Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity},
  author={Danny D. Nedialkova and Sebastian A Leidel},
  booktitle={Cell},
  year={2015}
}
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discrete codons elicits widespread protein aggregation in vivo. Using ribosome profiling, we find that loss of anticodon wobble uridine (U34) modifications in a subset of tRNAs leads to ribosome pausing… CONTINUE READING
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