Optimization of Apolipoprotein E Genotyping.

  title={Optimization of Apolipoprotein E Genotyping.},
  author={Addya and Xiaona Wang and Leonard},
  journal={Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology},
  volume={2 4},
Background: Three common alleles of apolipoprotein E (apoE) have been identified and are expressed codominantly to generate six genotypes. Different apoE genotypes are implicated in several cardiovascular and neurologic disorders. Testing for apoE genotypes has increasing diagnostic importance, particularly in the risk assessment of coronary artery disease. A reproducible and cost-effective assay was developed. Methods and Results: Polymerase chain reaction (PCR) amplification of the fourth… CONTINUE READING


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