Optimization of 5-flurouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer

@inproceedings{Yassin2010OptimizationO5,
  title={Optimization of 5-flurouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer},
  author={Alaa Eldeen Bakry Yassin and Md. Khalid Anwer and Hammam A. Mowafy and Ibrahim M. El-Bagory and Mohsen A. Bayomi and Ibrahim Abdullah Alsarra},
  booktitle={International journal of medical sciences},
  year={2010}
}
Solid lipid nanoparticle (SLNs) formulae were utilized for the release of 5-flurouracil (5-FU) inside the colonic medium for local treatment of colon cancer. SLNs were prepared by double emulsion-solvent evaporation technique (w/o/w) using triglyceride esters, Dynasan™ 114 or Dynasan™ 118 along with soyalecithin as the lipid parts. Different formulation parameters; including type of Dynasan, soyalicithin:Dynasan ratio, drug:total lipid ratio, and polyvinyl alcohol (PVA) concentration were… CONTINUE READING

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