Optimization issues in physiological toxicokinetic modeling: a case study with benzene.

@article{Woodruff1993OptimizationII,
  title={Optimization issues in physiological toxicokinetic modeling: a case study with benzene.},
  author={Tracey J. Woodruff and Fr{\'e}d{\'e}ric Y. Bois},
  journal={Toxicology letters},
  year={1993},
  volume={69 2},
  pages={181-96}
}
This paper compares two methods for global optimization of physiologically based toxicokinetic models: Monte Carlo optimization, which searches randomly for the optimum; and the simplex method, which updates systematically an array of parameter values. Two measures of goodness-of-fit are also contrasted: criterion function and likelihood. A 14-parameter… CONTINUE READING