Optimization and formulation design of carbopol loaded Piroxicam gel using novel penetration enhancers.

@article{Chaudhary2013OptimizationAF,
  title={Optimization and formulation design of carbopol loaded Piroxicam gel using novel penetration enhancers.},
  author={Hema Chaudhary and Ajay Rohilla and Permender Rathee and V. Barath Kumar},
  journal={International journal of biological macromolecules},
  year={2013},
  volume={55},
  pages={246-53}
}
The aim of the study was to develop and optimize Piroxicam transdermal gel formulation using three-factor, three-level Box-Behnken design by deriving a second-order polynomial equation to construct contour plots for prediction of responses as three selected independent variables with ratio of carbopol 974 (X1), ratio of propylene glycol (PG) (X2) and ratio of ethanol (X3). The dependent variables studied were the skin permeation rate of piroxicam (Y1), viscosity of the gel (Y2) and pH of the… CONTINUE READING

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