Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling.

@article{Aivado2005OptimizationAE,
  title={Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling.},
  author={Manuel A Aivado and Dimitrios Spentzos and Gil Alterovitz and Hasan H. Otu and Franck Grall and Aristoteles Achilles Nikolaus Giagounidis and Meghan P. Wells and Je-Yoel Cho and Ulrich Germing and Akos Gabor Czibere and Wolf Christian Prall and C{\'e}dric Porter and Marco F. Ramoni and T. A. Libermann},
  journal={Clinical chemistry and laboratory medicine},
  year={2005},
  volume={43 2},
  pages={
          133-40
        }
}
Surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry with protein arrays has facilitated the discovery of disease-specific protein profiles in serum. Such results raise hopes that protein profiles may become a powerful diagnostic tool. To this end, reliable and reproducible protein profiles need to be generated from many samples, accurate mass peak heights are necessary, and the experimental variation of the profiles must be known. We adapted the entire… CONTINUE READING

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