Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery.

@article{Rani2015OptimizationAE,
  title={Optimization and evaluation of bioactive drug-loaded polymeric nanoparticles for drug delivery.},
  author={Ruma Rani and Neeraj Dilbaghi and Dinesh Dhingra and Sandeep Kumar},
  journal={International journal of biological macromolecules},
  year={2015},
  volume={78},
  pages={
          173-9
        }
}
The premise of the present study was to suitably select or modify the constitution of the polymer matrix to achieve significantly high entrapment of hydrophilic drugs within polymeric nanoparticles (NPs). Glycyrrhizin (GL), the bioactive drug was selected as a representative hydrophilic drug. Ionotropic gelation technique was used for the preparation of glycyrrhizin-loaded NPs. Concentration of polymers were optimized by 3-level factorial design which affected the particle size and… CONTINUE READING
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