Optimization and characterization of primaquine–loaded solid lipid nanoparticles (SLN) for liver schinonticide targeting by freeze drying

  title={Optimization and characterization of primaquine–loaded solid lipid nanoparticles (SLN) for liver schinonticide targeting by freeze drying},
  author={James Jorum Owuor and Florence A Oloo and Daniel Ouma and Wesley Nyaigoti Omwoyo and Jeremiah Gathirwa},
The aim of this study was preparation of a liver schinonticide Primaquine phosphate PQ directly to the hepatocytes using solid lipid nanoparticles SLN The PQ loaded solid lipid nanoparticles PQ SLNs were prepared by a modified solvent emulsification evaporation method based on a water in oil in water w o w double emulsion and dried freeze drying PQ SLNFD to obtain the nanoparticles The mean particle size zeta potential drug loading and encapsulation efficiency of the PQ SLNFD were nm mV and… Expand

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