Optimised NLC: a nanotechnological approach to improve the anaesthetic effect of bupivacaine.

@article{Silva2017OptimisedNA,
  title={Optimised NLC: a nanotechnological approach to improve the anaesthetic effect of bupivacaine.},
  author={Gustavo H Rodrigues da Silva and L{\'i}gia Nunes de Morais Ribeiro and Hery Mitsutake and Viviane Aparecida Guilherme and Simone R Castro and Ronei Jesus Poppi and M{\'a}rcia Cristina Breitkreitz and Eneida de Paula},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={529 1-2},
  pages={253-263}
}
The short time of action and systemic toxicity of local anaesthetics limit their clinical application. Bupivacaine is the most frequently used local anaesthetic in surgical procedures worldwide. The discovery that its S(-) enantiomeric form is less toxic than the R(+) form led to the introduction of products with enantiomeric excess (S75:R25 bupivacaine) in… CONTINUE READING