Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters.

  title={Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters.},
  author={Michael R. Jacobs},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  volume={7 11},
To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. Patterns of antimicrobial activity fall into one of two major patterns: time-dependent killing and concentration-dependent killing. Time-dependent killing is characteristic of many antibiotic classes, such as beta-lactams and macrolides, and seeks to optimise the duration of exposure of a pathogen to an antimicrobial. The major PK/PD parameter… CONTINUE READING
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