Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin.

@article{Mann2004OptimisationOA,
  title={Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin.},
  author={Jamie F S Mann and Valerie A. Ferro and Alexander Balfour Mullen and Lawrence Tetley and Margaret M. Mullen and Katharine C. Carter and J. -P. Alexander and William H. Stimson},
  journal={Vaccine},
  year={2004},
  volume={22 19},
  pages={2425-9}
}
Vaccine antigens administered by the oral route are often degraded by gastric secretions during gastrointestinal transit. This necessitates larger and more frequent doses of antigen for vaccination. A delivery system, which overcomes this, is a lipid vesicle containing bile salts (bilosome), which prevents antigen degradation and enhances mucosal penetration. The effect of bilosome formulation modification on vaccine transit efficacy across the mucosa was determined. Specific antibody levels… CONTINUE READING

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