Optimisation Methods for Improving Fed-batch Cultivation of E . Coli Producing Recombinant Proteins

Abstract

Two optimisation techniques for the fed-batch cultivation of high cell density Escherichia coli producing recombinant proteins were compared. An unstructured model for the growth, based on the General State Space Dynamical Model [1] was used to represent the four major metabolic pathways: oxidative growth on glucose, fermentative growth on glucose… (More)

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