Optimality in the zonation of ammonia detoxification in rodent liver

@article{Bartl2015OptimalityIT,
  title={Optimality in the zonation of ammonia detoxification in rodent liver},
  author={Martin Bartl and Michael Pfaff and Ahmed G. Ghallab and Dominik Driesch and Sebastian G. Henkel and Jan G. Hengstler and Stefan Schuster and Christoph Kaleta and Rolf Gebhardt and Sebastian Zellmer and Pu Li},
  journal={Archives of Toxicology},
  year={2015},
  volume={89},
  pages={2069-2078}
}
Abstract The rodent liver eliminates toxic ammonia. In mammals, three enzymes (or enzyme systems) are involved in this process: glutaminase, glutamine synthetase and the urea cycle enzymes, represented by carbamoyl phosphate synthetase. The distribution of these enzymes for optimal ammonia detoxification was determined by numerical optimization. This in silico approach predicted that the enzymes have to be zonated in order to achieve maximal removal of toxic ammonia and minimal changes in… CONTINUE READING
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