Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction

@inproceedings{Kleibeuker2015OptimalTS,
  title={Optimal treatment scheduling of ionizing radiation and sunitinib improves the antitumor activity and allows dose reduction},
  author={Esther A. Kleibeuker and Matthijs A. ten Hooven and Kitty C M Castricum and Richard J. Honeywell and Arjan W Griffioen and Henk M W Verheul and Ben J. Slotman and Victor L Thijssen},
  booktitle={Cancer medicine},
  year={2015}
}
The combination of radiotherapy with sunitinib is clinically hampered by rare but severe side effects and varying results with respect to clinical benefit. We studied different scheduling regimes and dose reduction in sunitinib and radiotherapy in preclinical tumor models to improve potential outcome of this combination treatment strategy. The chicken chorioallantoic membrane (CAM) was used as an angiogenesis in vivo model and as a xenograft model with human tumor cells (HT29 colorectal… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 40 references

angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway

  • J Hong, Z Zhang, W Lv, M Zhang, C Chen, S Yang
  • Biochim Biophys Acta 2014 Feb 14
  • 2014

4T1 breast cancer cells

  • Y Shing, J Folkman, C Haudenschild, D Lund, R Crum, M. Klagsbrun
  • PLoS One 2013;8(8):e71347
  • 2013

renal cell carcinoma cells

  • KJ Gotink, HJ Broxterman, M Labots, RR de Haas, H Dekker, RJ Honeywell
  • Cancer Sci 2013 Aug;104(8):1052-61
  • 2013

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