Optimal time-points for minimal residual disease monitoring change on the basis of the method used in patients with acute myeloid leukemia who underwent allogeneic stem cell transplantation: a comparison between multiparameter flow cytometry and Wilms' tumor 1 expression.

@article{Rossi2015OptimalTF,
  title={Optimal time-points for minimal residual disease monitoring change on the basis of the method used in patients with acute myeloid leukemia who underwent allogeneic stem cell transplantation: a comparison between multiparameter flow cytometry and Wilms' tumor 1 expression.},
  author={Giovanni Rossi and Angelo Michele Carella and Maria Marta Minervini and Francesco Di Nardo and Chiara de Waure and Michele Mario Greco and Emanuela Merla and Giovanni Pio de Cillis and Nicola di Renzo and Angela Melpignano and Silvana Franca Capalbo and Gaetano Palumbo and Giovanni Pisapia and Nicola Cascavilla},
  journal={Leukemia research},
  year={2015},
  volume={39 2},
  pages={138-43}
}
Minimal residual disease (MRD) of 30 adult AML patients was monitored by multiparameter flow cytometry (MFC) and WT1 expression before and after allogeneic stem cell transplantation (allo-SCT). Diagnostic performance of pre-transplant MRD measured by MFC was higher than that obtained by WT1 expression. Comparable results were displayed at day +30 post-transplant, while better values by WT1 compared to MFC were found at day +90. Positive MRD by MFC predicted a shorter disease free survival (DFS… CONTINUE READING

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